alexa Chitosan-PVP-nano silver oxide wound dressing: in vitro and in vivo evaluation.
Genetics & Molecular Biology

Genetics & Molecular Biology

Journal of Molecular and Genetic Medicine

Author(s): Archana D, Singh BK, Dutta J, Dutta PK

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Abstract The main aim of this work was to prepare wound healing material with chitosan, poly vinyl pyrrolidone (PVP), silver oxide nanoparticles. The prepared chitosan, chitosan-PVP-nano silver oxide (CPS) films were characterized for their thermal behaviour, morphological properties, mechanical properties, antibacterial properties and wound healing properties. The CPS film found higher antibacterial activity because the materials both chitosan as well as silver oxide poses good antibacterial activity. L929 cell lines were for cytotoxicity study and Adult male albino rats (140-180 g) were used for wound healing study. The prepared film has more wound healing property than of cotton gauge, 100\% chitosan and other reported chitosan based dressings. Copyright © 2014 Elsevier B.V. All rights reserved. This article was published in Int J Biol Macromol and referenced in Journal of Molecular and Genetic Medicine

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