alexa Chlorpyrifos: a ten-year US poison center exposure experience.
Clinical Research

Clinical Research

Journal of Clinical Case Reports

Author(s): Kingston RL, Chen WL, Borron SW, Sioris LJ, Harris CR,

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Abstract We performed a retrospective review of data based on poison center exposure inquiries related to chlorpyrifos (CP) and the corresponding poison center-determined medical outcomes reported to the Toxic Exposure Surveillance System (TESS) of the American Association of Poison Control Centers. Ten y (1985-1994) of TESS data were obtained. Medical outcomes representing all inquiries, accidental/unintentional inquiries, and intentional/suicidal inquiries were tabulated. Published TESS data was also tabulated to allow comparison of CP exposure inquiries to all non-pharmaceutical and insecticides/pesticides exposure inquiries for like time periods. Frequency of antidote use, product sales data, CP-related fatality reports, and pertinent issues related to telephone derived surveillance data were also reviewed; 36, 183 CP exposure inquiries were identified. Of all CP exposure inquiries, 27, 473 (75.9\%) were assessed as having no significant health consequences; 4,511 (12.5\%) outcomes were judged unrelated and 2,980 (8.2\%) were unable to be followed. Reported significant medical outcomes for the remaining exposure inquiries were moderate 1,092 (3.0\%), major 119 (0.3\%) and death 8 (0.02\%). Considering only calls with outcomes judged causally related to CP, where a given level of effect could reasonably be determined, 95.8\% (27,473/28,692) of these calls resulted in no significant health effects. Use of antidotes specific to organophosphates were infrequent [atropine, 1.0\% (385) and 2-PAM, 0.5\% (177) of all cases respectively]. Despite the number of reported CP exposure inquiries, relatively few resulted in outcomes of consequence. TESS data suggested that the majority of patients undergoing medical evaluation and/or treatment after a suspected CP exposure do not require specific antidotes. TESS data serves as a useful first step in evaluating product safety. Assessment of product toxicity requires additional investigation of reported adverse effects and circumstances related to the incident.
This article was published in Vet Hum Toxicol and referenced in Journal of Clinical Case Reports

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