alexa Cholesterol modulates glycolipid conformation and receptor activity.
Bioinformatics & Systems Biology

Bioinformatics & Systems Biology

Journal of Glycomics & Lipidomics

Author(s): Lingwood D, Binnington B, Rg T, Vattulainen I, Grzybek M

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Abstract We document a new dimension of surface recognition in which communication is controlled through the collective behavior of lipids. Membrane cholesterol induces a tilt in glycolipid receptor headgroup, resulting in loss of access for ligand binding. This property appears to organize erythrocyte blood group presentation and glycolipid receptor function during the activation of sperm fertility, suggesting that lipid 'allostery' is a means to regulate membrane recognition processes.

This article was published in Nat Chem Biol and referenced in Journal of Glycomics & Lipidomics

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