Author(s): Sawaki L, Boroojerdi B, KaelinLang A, Burstein AH, Btefisch CM,
Abstract Share this page
Abstract Motor practice elicits use-dependent plasticity in humans as well as in animals. Given the influence of cholinergic neurotransmission on learning and memory processes, we evaluated the effects of scopolamine (a muscarinic receptor antagonist) on use-dependent plasticity and corticomotor excitability in a double-blind placebo-controlled randomized design study. Use-dependent plasticity was substantially attenuated by scopolamine in the absence of global changes in corticomotor excitability. These results identify a facilitatory role for cholinergic influences in use-dependent plasticity in the human motor system.
This article was published in J Neurophysiol
and referenced in International Journal of Neurorehabilitation