Author(s): Meshorer E, Misteli T
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Abstract Embryonic stem (ES) cells are unique in that they are pluripotent and have the ability to self-renew. The molecular mechanisms that underlie these two fundamental properties are largely unknown. We discuss how unique properties of chromatin in ES cells contribute to the maintenance of pluripotency and the determination of differentiation properties.
This article was published in Nat Rev Mol Cell Biol
and referenced in Journal of Bioengineering & Biomedical Science