alexa Chromatin Structure of Epstein-Barr Virus Latent Episomes.
Chemistry

Chemistry

Medicinal chemistry

Author(s): Lieberman PM

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Abstract EBV latent infection is characterized by a highly restricted pattern of viral gene expression. EBV can establish latent infections in multiple different tissue types with remarkable variation and plasticity in viral transcription and replication. During latency, the viral genome persists as a multi-copy episome, a non-integrated-closed circular DNA with nucleosome structure similar to cellular chromosomes. Chromatin assembly and histone modifications contribute to the regulation of viral gene expression, DNA replication, and episome persistence during latency. This review focuses on how EBV latency is regulated by chromatin and its associated processes. This article was published in Curr Top Microbiol Immunol and referenced in Medicinal chemistry

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