Author(s): Venkitaraman AR
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Abstract Aberrations in the number and structure of chromosomes are a common feature of cells from solid tumours. In this brief review, I summarize the evidence that there is a causal relationship between chromosomal instability and the initiation or progression of cancer, and argue that the co-existence of both forms of instability in many solid tumours reflects mechanistic and functional interdependencies that remain poorly investigated.
This article was published in Cell Cycle
and referenced in Journal of Addiction Research & Therapy