Author(s): Jagjit Singh GK, Ijaz S, Rockwood N, Farnworth SP, Devitt E,
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Abstract Chronic Hepatitis E infection (HEV) is reported in immunocompromised patients. A 45-year-old HIV-infected man had no cause found for a persistent transaminitis which predated commencement of antiretroviral therapy. Hepatic elastography and liver biopsy revealed cirrhosis. In 2010, he tested positive for HEV IgM/IgG antibodies. Plasma HEV RNA was detected. Archived samples revealed HEV viraemia since 2000. A 24-week course of pegylated interferon was commenced and HEV RNA became undetectable at week 4 until week 27 post treatment cessation. Chronic HEV infection should be considered in HIV patients as a cause for unexplained transaminitis and cryptogenic liver cirrhosis. Copyright © 2011 The British Infection Association. Published by Elsevier Ltd. All rights reserved.
This article was published in J Infect
and referenced in Journal of Antivirals & Antiretrovirals