alexa Cleavage of proBDNF by tPA plasmin is essential for long-term hippocampal plasticity.
Neurology

Neurology

Autism-Open Access

Author(s): Pang PT, Teng HK, Zaitsev E, Woo NT, Sakata K,

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Abstract Long-term memory is thought to be mediated by protein synthesis-dependent, late-phase long-term potentiation (L-LTP). Two secretory proteins, tissue plasminogen activator (tPA) and brain-derived neurotrophic factor (BDNF), have been implicated in this process, but their relationship is unclear. Here we report that tPA, by activating the extracellular protease plasmin, converts the precursor proBDNF to the mature BDNF (mBDNF), and that such conversion is critical for L-LTP expression in mouse hippocampus. Moreover, application of mBDNF is sufficient to rescue L-LTP when protein synthesis is inhibited, which suggests that mBDNF is a key protein synthesis product for L-LTP expression. This article was published in Science and referenced in Autism-Open Access

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