Author(s): Geldof BA, Roesyanto ID, van Joost T
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Abstract Sensitization by para-tertiary-butylphenolformaldehyde resin (PTBP-FR), which is particularly useful as a leather glue, has been known for 30 years. We retrospectively studied the clinical aspects of those patients with a PTBP-FR allergy among 1966 patients in whom contact dermatitis was confirmed by patch testing. A positive patch test to PTBP-FR was present in 30 patients (1.5\%), 24 of whom were women. Exposure to PTBP-FR as a cause of the dermatitis was "certain" in 7, "very likely" in 6 and "unclear" in 17. 67.7\% of the patients had a multiple allergy. In 43.3\% of the patients, a history of atopy was found. No clear association of PTBP-FR sensitization with allergies to phenolformaldehyde resin (P-FR) or free para-tertiary-butylphenol (PTBP) emerged in this group of 30 patients. This study supports the hypothesis that PTBP-FR and P-FR do not contain the same sensitizers. Follow-up of 26 of the 30 patients showed a favourable course, dependent on identification of the source of exposure, avoidance of further contact and absence of sensitization to multiple allergens.
This article was published in Contact Dermatitis
and referenced in Journal of Allergy & Therapy