Author(s): Chowers MY, Lang R, Nassar F, BenDavid D, Giladi M,
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Abstract West Nile (WN) virus is endemic in Israel. The last reported outbreak had occurred in 1981. From August to October 2000, a large-scale epidemic of WN fever occurred in Israel; 417 cases were confirmed, with 326 hospitalizations. The main clinical presentations were encephalitis (57.9\%), febrile disease (24.4\%), and meningitis (15.9\%). Within the study group, 33 (14.1\%) hospitalized patients died. Mortality was higher among patients >70 years (29.3\%). On multivariate regressional analysis, independent predictors of death were age >70 years (odds ratio [OR] 7.7), change in level of consciousness (OR 9.0), and anemia (OR 2.7). In contrast to prior reports, WN fever appears to be a severe illness with high rate of central nervous system involvement and a particularly grim outcome in the elderly.
This article was published in Emerg Infect Dis
and referenced in Journal of Meningitis