alexa Clinical features of bleb-related infection: a 5-year survey in Japan.


Journal of Clinical & Experimental Ophthalmology

Author(s): Yamamoto T, Kuwayama Y, Kano K, Sawada A, Shoji N Study Group fo

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Abstract PURPOSE: To present clinical features and microbial data for bleb-related infections obtained by the 5-year-long Japan Glaucoma Society Survey of Bleb-related Infection (JGSSBI). METHODS: This multicentre prospective observational study was conducted in 82 clinical centres in Japan. A total of 170 bleb-related infections developed in 157 eyes of 156 patients during a 5-year period. The ophthalmological and microbial data were analysed. RESULTS: The patient age at first infection was 59.3 ± 17.7 years [mean ± standard deviation (SD)], and the period between the last glaucoma surgery and the first infection was 6.9 ± 5.8 years (mean ± SD; range: 0.3-41 years). Bleb leakage was noted significantly more frequently in eyes with repeated infections. The stage of infection at diagnosis was stage I in 91 infections (54\%), stage II in 30 infections (18\%), stage IIIa in 18 infections (11\%), and stage IIIb in 31 infections (18\%). Staphylococcus species were the most frequently isolated microbe (41\%), followed by Streptococcus species (32\%). Streptococcus species, coagulase-negative Staphylococcus, Haemophilus influenzae, and Enterococcus species were the major bacteria isolated in the late-stage infections. CONCLUSIONS: The JGSSBI project has revealed several characteristics of bleb-related infection in Japan, which include the significance of bleb leakage in the development of repeated infections and the distribution of bacterial isolates. © 2012 The Authors. Acta Ophthalmologica © 2012 Acta Ophthalmologica Scandinavica Foundation. This article was published in Acta Ophthalmol and referenced in Journal of Clinical & Experimental Ophthalmology

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