alexa Clinical importance of the cytochromes P450.
Toxicology

Toxicology

Journal of Drug Metabolism & Toxicology

Author(s): Nebert DW, Russell DW, Nebert DW, Russell DW

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Abstract The human cytochrome P450 (CYP) superfamily comprises 57 genes. These genes code for enzymes that can have a role in: metabolism of drugs, foreign chemicals, arachidonic acid and eicosanoids; cholesterol metabolism and bile-acid biosynthesis; steroid synthesis and metabolism; vitamin D(3) synthesis and metabolism; retinoic acid hydroxylation; and those of still unknown function. Cytochrome P450 was once believed to be mainly a hepatic drug detoxication system, but is now understood to include a myriad of enzymic reactions implicated in important life processes. Mutations in many CYP genes cause inborn errors of metabolism and contribute to many clinically relevant diseases. This article was published in Lancet and referenced in Journal of Drug Metabolism & Toxicology

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