alexa Clinical manifestations and coronary artery disease risk factors at diagnosis of systemic lupus erythematosus: data from an international inception cohort.
Immunology

Immunology

Rheumatology: Current Research

Author(s): Urowitz MB, Gladman D, Ibaez D, Fortin P, SanchezGuerrero J,

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Abstract Systemic Lupus International Collaborating Clinics (SLICC) comprises 27 centres from 11 countries. An inception cohort of 918 SLE patients has been assembled according to a standardized protocol between 2000 and 2006. Clinical features, classic coronary artery disease (CAD) risk factors, as well as other potential risk factors were collected. Of the 918 patients 89\% were females, and of multi racial origin. Less than half the patients were living in a permanent relationship, 58\% had post secondary education and 51\% were employed. Eight percent had family history of SLE. At enrolment, with at mean age of diagnosis of 34.5 years, a significant number of patients already had CAD risk factors, such as hypertension (33\%) and hypercholesterolemia (36\%). Only 15\% of the patients were postmenopausal, 16\% were current smokers and 3.6\% had diabetes at entry to the SLICC-RAS (Registry for Atherosclerosis). A number of patients in this multi-racial, multi-ethnic inception cohort of lupus patients have classic CAD risk factors within a mean of 5.4 months from diagnosis. This cohort will be increased to 1500 patients to be followed yearly for 10 years. This will provide a unique opportunity to evaluate risk factors for accelerated atherosclerosis in SLE. This article was published in Lupus and referenced in Rheumatology: Current Research

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