Author(s): Poetker SK, Porto AF, Giozza SP, Muniz AL, Caskey MF,
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Abstract BACKGROUND: Human T-lymphotropic virus type 1 (HTLV-1) is known to cause HTLV-associated myelopathy (HAM)/tropical spastic paraparesis and adult T cell leukemia. A growing body of evidence links HTLV-1 infection with an increasing spectrum of disease, including uveitis, periodontal disease, arthropathy, sicca syndrome, and neurologic deficits. OBJECTIVES: Despite recent findings, the natural history of HTLV-1 infection remains poorly defined. This study was designed to better characterize initial clinical and neurological findings in individuals diagnosed with HTLV-1 infection. STUDY DESIGN: We conducted a cross-sectional study of 71 individuals recently diagnosed with HTLV-1 and 71 uninfected age- and sex-matched blood donors in Salvador, Brazil. Subjects were administered a standardized questionnaire and underwent physical exam. RESULTS: HTLV-1 infected subjects were significantly more likely than controls to report complaints of hand and foot numbness (OR=5.3; 95\% CI: 1.8-15.3; p=0.002 and OR=4.0; 95\% CI: 1.3-12; p=0.013 respectively), difficulty running (OR=4.0; 95\% CI: 1.1-14.2; p=0.032), nocturia (OR=5.0; 95\% CI: 1.1-22.8; p=0.038), arthralgia (OR=3.3; 95\% CI: 1.4-7.7; p=0.006), and photophobia (OR=3.3; 95\% CI: 1.4-7.7; p=0.006). CONCLUSIONS: Neurologic, ocular and rheumatologic complaints may be the first manifestations of HTLV-1 infection. Therefore, all patients presenting with initial diagnosis should be rigorously screened for these symptoms. Copyright © 2011 Elsevier B.V. All rights reserved.
This article was published in J Clin Virol
and referenced in Epidemiology: Open Access