Author(s): Dai FR, Peng GQ, Zhang Y, Chen CX
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Abstract OBJECTIVE: To explore the clinical features, diagnosis, treatment and prognosis of endometrial carcinoma in young, middle-aged and elderly women. METHODS: We retrospectively analyzed the clinical data of 82 cases of endometrial carcinoma in young, middle-aged women and 33 cases of endometrial cacinoma in elderly women. RESULTS: The rates of adenocarcinoma in young, middle-aged and elderly groups were 74.4\% and 75.5\%, respectively. The young,middle-aged and elderly patients with Stage I endometrial cancer were 64.6\% and 69.7\%, and those with Stage III and IV were 15.9\% and 15.2\%, respectively. The histological Grade 1 carcinoma of endometrium in young,middle-aged and elderly women were 70.7\% and 60.6\%, respectively. The young, middle-aged women without myometrial invasion were more than the elderly women (42.8\% vs 15.6\%, P < 0.01). The young, middle-aged women with myometrial invasion more than half of myometrial wall were less than the elderly women (10.4\% vs 40.6\%, P < 0.01). The rate of chemical treatment after the surgery in the elderly women was more than that of the young, middle-aged women (P < 0.05). The 5-year survival rate of the young, middle-aged women was obviously higher than that of the elderly women (92.79\% vs 72.21\%, P < 0.05). CONCLUSION: Adenocarcinoma and well-differentiated cells are the main pathological characteristics of endometrial carcinoma both in the young, middle-aged and the elderly women. Most young, middle-aged and el-derly patients can be diagnosed and treated in the early stage. Early diagnosis and reasonable treatment can improve the prognosis. The prognosis of the young, middle-aged patients is obviously better than that of the elderly patients, and the myometrial invasion depth may be the main difference.
This article was published in Zhong Nan Da Xue Xue Bao Yi Xue Ban
and referenced in Journal of Clinical Case Reports