alexa Clinical rubella reinfection during pregnancy in a previously vaccinated woman.


Journal of Vaccines & Vaccination

Author(s): Aboudy Y, Barnea B, Yosef L, Frank T, Mendelson E

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Abstract We report a documented case of clinically apparent rubella reinfection during pregnancy with rubelliform rash and fever followed by lymphodenopathy at the 18th week of gestation, in a previously vaccinated woman with haemagglutination inhibition (HI) antibody titre of 1:32. The serological tests results (including neutralizing antibodies) demonstrated a significant rise in her rubella specific IgG level with strongly positive IgM reactivity. In addition, rubella-specific IgG antibody avidity testing displayed high avidity index (53-88\%) typical of rubella reinfection. Umbilical cord blood, drawn by sonographic-guided cordocentesis at 24 weeks' gestation, was found to be negative for rubella-specific IgM antibody. The pregnancy was continued to term, and a healthy infant was born. Copyright 2000 The British Infection Society. This article was published in J Infect and referenced in Journal of Vaccines & Vaccination

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