alexa Clinical studies with a low dose estrogen-progestogen combination.
Pharmaceutical Sciences

Pharmaceutical Sciences

Journal of Bioequivalence & Bioavailability

Author(s): Sartoretto JN, OrtegaRecio JC, Moraes R, Filho FN

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Abstract PIP: The effectiveness and acceptability of a low-dose oral contraceptive containing 150 mcg d-norgestrel plus 30 mcg ethinyl estradiol was evaluated in 930 women over a total of 7197 cycles. 7 pregnancies occurred, though only 1 was attributable to method failure. Based on the life-table method, the cumulative termination rate, by reason of pregnancy, was .01 after 12 cycles, while the total cumulative termination rate was .47 after 12 cycles. Cycle control was good in lactating women, though not as good as in new acceptors and patients who had previously used other oral contraceptive preparations. More than 6 days of menstrual bleeding, including menses, breakthrough bleeding, and spotting, were recorded in only 5.2\% of the cycles. Other side effects were minimal. No marked alterations in body weight or diastolic blood pressure were reported.
This article was published in Contraception and referenced in Journal of Bioequivalence & Bioavailability

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