alexa [Clinical study in treating intractable ulcerative colitis with traditional Chinese medicine].
Immunology

Immunology

Journal of Inflammatory Bowel Diseases & Disorders

Author(s): Chen ZS, Nie ZW, Sun QL

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Abstract Clinical double blind study in treating 153 intractable ulcerative colitis with Chinese medicinal herbs was conducted, the patients were randomly assigned to three groups. Group I is administered with Jian Pi Ling (JPL) tablet with retention-enema of Radix Sophorae Flavescentis and Flos Sophora (RSF-FS) decoction per night, group II with salicylazosulfapyridine (SASP) and retention-enema of dexamethasone, group III with placebo and retention-enema of decoction as that in group I. After 90 days every patients were checked by means of fibro-enteroscope, pathologic and immunologic parameters. THE RESULTS: the curative rates of group I, II, III, were 53.1\%, 27.7\% and 19.0\%, the total effective rates were 85.9\%, 59.6\% and 45.2\% respectively. By comparison among groups, the efficacy of group I was the best (P < 0.01). The check of T and B lymphocyte subpopulation showed the B lymphocyte of group I markedly decreased, OKT3 and OKT8 obviously increased, the ratio of OKT4 and OKT8 approached normal value. The amount of IgG, IgM, C3 increased abnormally, decreased dramatically after medication, while those of group II and III have not changed significantly. The bacteriostatic test in vitro showed the bacteriostatic effect of RSF-FS on pathogenic B. coli, Shigella dysenteriae and Staphylococcus aureus was the best, that of solution Jian Pi Ling the next, that of SASP was the least effective. Therefore, the principle and method of group I seems to be the best therapeutic programme.
This article was published in Zhongguo Zhong Xi Yi Jie He Za Zhi and referenced in Journal of Inflammatory Bowel Diseases & Disorders

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