Author(s): Horie Y, Udagawa M, Hirayama C
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Abstract A 43-yr-old man with abdominal fullness was treated with oral cimetidine during remission of acute intermittent porphyria. Urinary prophobilinogen and porphyrins were not altered by the treatment, but urinary delta-aminolevulinic acid decreased, and abdominal fullness disappeared. Thus, cimetidine may control acute intermittent porphyria by inhibiting hepatic delta-aminolevulinic acid synthetase.
This article was published in Clin Chim Acta
and referenced in Journal of Blood Disorders & Transfusion