alexa Clinicopathologic and molecular features of 122 Brazilian cases of nodal and extranodal NK T-cell lymphoma, nasal type, with EBV subtyping analysis.


Journal of Blood Disorders & Transfusion

Author(s): Gualco G, DomenyDuarte P, Chioato L, Barber G, Natkunam Y, , Gualco G, DomenyDuarte P, Chioato L, Barber G, Natkunam Y,

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Abstract Extranodal natural killer/T-cell lymphoma, nasal type (NK/TCL) is more prevalent in Asia and in some areas of South and Central America, but it is rarely seen in the United States and Europe. In this study, a series of 122 cases of NK/TCL from Brazil was analyzed with respect to clinicopathologic features. Clinical characteristics and geographic distribution were evaluated in 97 cases of nasal/nasopharyngeal region and 23 cases in extranasal sites including 6 nodal cases. Clinical staging and follow-up information was available in a subset of 21 patients. All cases harbored Epstein-Barr virus (EBV), 95\% and 85\% expressed cytoplasmic CD3 and CD56, respectively, and all cases were positive for at least 1 marker for cytotoxic granules. The global distribution of EBV subtypes showed predominance of strain subtype A, 89\%, and subtype B, 11\%. No dual infections were detected. TCR-γ TCR-gene rearrangement was observed in 7 cases; all of them extranodal. Three of TCR-γ(+) cases showed EBV subtype A. Two TCR-γ(+)/CD56(+) cases showed EBV subtype B. Geographic distribution of NK/TCL showed higher frequency in the southeast and northeast regions of Brazil. Striking differences among geographic regions were seen with the vast majority of EBV subtype B (86\%) occurring in the south and southeast regions. This article was published in Am J Surg Pathol and referenced in Journal of Blood Disorders & Transfusion

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