Author(s): BradyWest D, Blake G
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Abstract OBJECTIVE: A retrospective observational study was done to describe the clinical and pathological profile of gastrointestinal stromal tumors (GISTs) in Afro-Caribbean patients at a tertiary care referral center over a 5-year period. RESULTS: Eighteen cases of GIST were identified over the period under review. Male to female ratio was 1.25:1, the mean age was 54.7 years, and abdominal pain (44\%) and gastrointestinal bleeding (50\%) were the predominant presenting symptoms. The majority of tumors were of gastric location (83\%) and spindle cell morphology (66\%). C-kit (CD117) positivity was found in 13 of 14 (93\%) cases tested. Using current guidelines for assigning risk of aggressive behavior, 44\% of tumors were considered high risk. Of the 10 patients with high-risk or intermediate-risk tumors, 4 died, 1 of which had developed resistance to imatinib therapy. CONCLUSION: In this group of patients, GISTs demonstrated predominantly gastric location and spindle cell morphology and a guarded outlook for more aggressive tumors, which is moderated in the long-term by imatinib resistance.
This article was published in J Natl Med Assoc
and referenced in Journal of Gastrointestinal & Digestive System