alexa Clinicopathological features and outcome of gastrointestinal stromal tumors in an Afro-Caribbean population.


Journal of Gastrointestinal & Digestive System

Author(s): BradyWest D, Blake G

Abstract Share this page

Abstract OBJECTIVE: A retrospective observational study was done to describe the clinical and pathological profile of gastrointestinal stromal tumors (GISTs) in Afro-Caribbean patients at a tertiary care referral center over a 5-year period. RESULTS: Eighteen cases of GIST were identified over the period under review. Male to female ratio was 1.25:1, the mean age was 54.7 years, and abdominal pain (44\%) and gastrointestinal bleeding (50\%) were the predominant presenting symptoms. The majority of tumors were of gastric location (83\%) and spindle cell morphology (66\%). C-kit (CD117) positivity was found in 13 of 14 (93\%) cases tested. Using current guidelines for assigning risk of aggressive behavior, 44\% of tumors were considered high risk. Of the 10 patients with high-risk or intermediate-risk tumors, 4 died, 1 of which had developed resistance to imatinib therapy. CONCLUSION: In this group of patients, GISTs demonstrated predominantly gastric location and spindle cell morphology and a guarded outlook for more aggressive tumors, which is moderated in the long-term by imatinib resistance.
This article was published in J Natl Med Assoc and referenced in Journal of Gastrointestinal & Digestive System

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Relevant Topics

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version