alexa Clonal evolution in cancer
Mathematics

Mathematics

Journal of Applied & Computational Mathematics

Author(s): Mel Greaves

Abstract Share this page

Cancers evolve by a reiterative process of clonal expansion, genetic diversification and clonal selection within the adaptive landscapes of tissue ecosystems. The dynamics are complex, with highly variable patterns of genetic diversity and resulting clonal architecture. Therapeutic intervention may destroy cancer clones and erode their habitats, but it can also inadvertently provide a potent selective pressure for the expansion of resistant variants. The inherently Darwinian character of cancer is the primary reason for this therapeutic failure, but it may also hold the key to more effective control.

This article was published in Nature and referenced in Journal of Applied & Computational Mathematics

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