alexa Co-expression of interleukin-2 by a bicistronic plasmid increases the efficacy of DNA immunization to prevent influenza virus infections.
Immunology

Immunology

Journal of Vaccines & Vaccination

Author(s): Henke A, Rohland N, Zell R, Wutzler P

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Abstract A promising approach to protect susceptible individuals against severe diseases is the inoculation of plasmids. Such DNA vaccines against influenza virus infections were quite efficient in different animal models; but still this procedure is not in clinical use until today. The present study reports the generation and characterization of bicistronic plasmids which enables the expression of influenza A virus gene sequences together with immunostimulatory cytokines demonstrating that among these cytokines especially interleukin-2 (IL-2) was efficient to prevent a lethal influenza virus infection in mice. Copyright 2006 S. Karger AG, Basel. This article was published in Intervirology and referenced in Journal of Vaccines & Vaccination

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