alexa Cognitive deterioration after venlafaxine overdose.
Psychiatry

Psychiatry

Journal of Addiction Research & Therapy

Author(s): GarcaCabeza I, de Blas MM, Epifanio MM, de Chvez MG

Abstract Share this page

Abstract BACKGROUND: Venlafaxine is an antidepressant whose adverse event profile is similar to that of the SSRIs (selective serotonin reuptake inhibitors). Serious complications due to venlafaxine overdose have been described. These generally have been resolved with supportive measures alone. However, although patients usually recover even after massive intake of the drug, death may occur in rare cases. OBJECTIVE: This article reports a case of dementia after an overdose of venlafaxine. CASE REPORT: We present a case of severe cognitive deterioration in a 48-year-old woman after venlafaxine overdose in a suicide attempt. She became comatose after the overdose. On recovery from the coma, she suffered irreversible motor and cognitive alterations and seizures. Several factors could justify the possible association of these side effects with venlafaxine overdose: time relationship, severe focal deficit and other neurological signs, symptomatic fluctuation, relationship of serotonin networks with the cognitive functions and deficits related to the network damage, and the potential capacity of venlafaxine to damage the central nervous system. However, other alternatives, especially factors that could implicate a hypoxic encephalopathy as the origin of the dementia, cannot be entirely ruled out. CONCLUSION: Venlafaxine seems to have special toxicity vis-à-vis the SSRIs, and this case adds to the literature supporting this. Cognitive function should be monitored after an overdose with venlafaxine. Copyright © 2011 Elsevier Inc. All rights reserved. This article was published in J Emerg Med and referenced in Journal of Addiction Research & Therapy

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords