alexa Cohesin: its roles and mechanisms.
Molecular Biology

Molecular Biology

Journal of Cytology & Histology

Author(s): Nasmyth K, Haering CH

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Abstract The cohesin complex is a major constituent of interphase and mitotic chromosomes. Apart from its role in mediating sister chromatid cohesion, it is also important for DNA double-strand-break repair and transcriptional control. The functions of cohesin are regulated by phosphorylation, acetylation, ATP hydrolysis, and site-specific proteolysis. Recent evidence suggests that cohesin acts as a novel topological device that traps chromosomal DNA within a large tripartite ring formed by its core subunits. This article was published in Annu Rev Genet and referenced in Journal of Cytology & Histology

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