Author(s): Fischbach MA
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Abstract New drug development strategies are needed to combat antimicrobial resistance. The object of this perspective is to highlight one such strategy: treating infections with sets of drugs rather than individual drugs. We will highlight three categories of combination therapy: those that inhibit targets in different pathways; those that inhibit distinct nodes in the same pathway; and those that inhibit the very same target in different ways. We will then consider examples of naturally occurring combination therapies produced by micro-organisms, and conclude by discussing key opportunities and challenges for making more widespread use of drug combinations. Copyright © 2011 Elsevier Ltd. All rights reserved.
This article was published in Curr Opin Microbiol
and referenced in Journal of Antimicrobial Agents