Author(s): Ejim L, Farha MA, Falconer SB, Wildenhain J, Coombes BK,
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Abstract Combinations of antibiotics are commonly used in medicine to broaden antimicrobial spectrum and generate synergistic effects. Alternatively, combination of nonantibiotic drugs with antibiotics offers an opportunity to sample a previously untapped expanse of bioactive chemical space. We screened a collection of drugs to identify compounds that augment the activity of the antibiotic minocycline. Unexpected synergistic drug combinations exhibited in vitro and in vivo activity against bacterial pathogens, including multidrug-resistant isolates.
This article was published in Nat Chem Biol
and referenced in Journal of Medical Microbiology & Diagnosis