alexa Combined treatment of HEDTA and propolis prevents aluminum induced toxicity in rats.
Genetics & Molecular Biology

Genetics & Molecular Biology

Journal of Molecular Biomarkers & Diagnosis

Author(s): Bhadauria M

Abstract Share this page

Abstract A study was undertaken to evaluate protective effect of chelating agent, N-(2-hydroxy ethyl ethylene diamine triacetic acid) [HEDTA] with and without propolis against aluminum (Al) induced toxicity in liver, kidney and brain. Toxicity was induced by single administration of aluminum nitrate at a dose of 32.5mg/kg (½ of LD(50)). HEDTA (20mg/kg, ip), propolis (200mg/kg, po), and combination of HEDTA and propolis, respectively, were administered for 3 days after 24h of Al exposure. Significant enhancement in AST, ALT, uric acid, urea, cholesterol, and triglyceride contents was found in serum, whereas albumin was decreased after Al exposure. Hepatic, renal, and neuronal LPO were found significantly increased after Al exposure, whereas it inhibited AChE activity in forebrain, midbrain, and hindbrain. Al significantly reduced the activity of adenosine triphosphatase, superoxide dismutase and catalase and GSH contents in hepatic, renal and nervous tissues. However, individual treatment of HEDTA and propolis restored biochemical parameters towards control but combined treatment of HEDTA and propolis offered better protection in comparison to monotherapy. Combined treatment of HEDTA and propolis preserved histological features, mitigated oxidative stress and improved liver, kidney and brain functions more profoundly. Copyright © 2012 Elsevier Ltd. All rights reserved. This article was published in Food Chem Toxicol and referenced in Journal of Molecular Biomarkers & Diagnosis

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

  • 9th International Conference and Expo on Molecular & Cancer Biomarkers
    August 23-24, 2017 Birmingham, UK
  • 2nd International Conference on Medical Imaging and Diagnosis
    London, UK
  • 22nd International Conference on Cancer Drugs and Therapeutics
    Paris, France
  • International Conference on Oncology Nursing and Cancer Care
    Singapore City, Singapore
  • World Summit on Cell Signalling and Cancer Therapy
    Toronto, Canada
  • International Conference on Radiology and Imaging
    New York, USA

Relevant Topics

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version