alexa Combining quantum mechanical ligand conformation analysis and protein modeling to elucidate GPCR-ligand binding modes.
Clinical Sciences

Clinical Sciences

Cardiovascular Pharmacology: Open Access

Author(s): Schultes S, Engelhardt H, Roumen L, Zuiderveld OP, Haaksma EE, , Schultes S, Engelhardt H, Roumen L, Zuiderveld OP, Haaksma EE,

Abstract Share this page

Abstract SAR beyond protein-ligand interactions: By combining structure-affinity relationships, protein-ligand modeling studies, and quantum mechanical calculations, we show that ligand conformational energies and basicity play critical roles in ligand binding to the histamine H4 receptor, a GPCR that plays a key role in inflammation. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. This article was published in ChemMedChem and referenced in Cardiovascular Pharmacology: Open Access

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version