Author(s): DeLeo FR, Otto M, Kreiswirth BN, Chambers HF, DeLeo FR, Otto M, Kreiswirth BN, Chambers HF, DeLeo FR, Otto M, Kreiswirth BN, Chambers HF, DeLeo FR, Otto M, Kreiswirth BN, Chambers HF
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Abstract Meticillin-resistant Staphylococcus aureus (MRSA) is endemic in hospitals worldwide, and causes substantial morbidity and mortality. Health-care-associated MRSA infections arise in individuals with predisposing risk factors, such as surgery or presence of an indwelling medical device. By contrast, many community-associated MRSA (CA-MRSA) infections arise in otherwise healthy individuals who do not have such risk factors. Additionally, CA-MRSA infections are epidemic in some countries. These features suggest that CA-MRSA strains are more virulent and transmissible than are traditional hospital-associated MRSA strains. The restricted treatment options for CA-MRSA infections compound the effect of enhanced virulence and transmission. Although progress has been made towards understanding emergence of CA-MRSA, virulence, and treatment of infections, our knowledge remains incomplete. Here we review the most up-to-date knowledge and provide a perspective for the future prophylaxis or new treatments for CA-MRSA infections. Copyright 2010 Elsevier Ltd. All rights reserved.
This article was published in Lancet
and referenced in Journal of Medical Microbiology & Diagnosis