Author(s): Rajadurai M, Prince PS
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Abstract INTRODUCTION: We demonstrate the effect of Aegle marmelos leaf extract (AMLEt) and alpha-tocopherol on plasma lipids, lipid peroxides and marker enzymes in rats with isoproterenol (ISO)-induced myocardial infarction. METHODS: Rats were pre-treated orally for 35 days with different doses of an aqueous AMLEt (50 mg/ kg, 100 mg/kg and 200 mg/kg) prior to ISO-induced myocardial infarction. The effects on creatine kinase, lactate dehydrogenase, plasma thiobarbituric acid reactive substances, lipid hydroperoxides, serum lipids and lipoproteins were studied. RESULTS: Pre-treatment with AMLEt at doses of 100 mg/kg and 200 mg/kg bodyweight for 35 days showed a significant effect on the activities of marker enzymes, lipid peroxides, lipids, lipoproteins and antioxidant enzymes in ISO-treated rats. The effect of AMLEt 200 mg/kg was found to be equal to the effect of alpha-tocopherol 60 mg/kg. CONCLUSION: Aegle marmelos leaves possess antihyperlipidaemic effect in rats with ISO-induced myocardial infarction.
This article was published in Singapore Med J
and referenced in Biochemistry & Physiology: Open Access