alexa Comparative evaluation of single dose regimen with two dose regimen of fluconazole in the treatment of tinea versicolor: A double blind placebo controlled study.


Journal of Microbial & Biochemical Technology

Author(s): Balachandran C Thajuddin, Ravikumar BC

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Abstract In a double blind randomised study to assess the efficacy of single dose fluconazole therapy, 30 patients of tinea versicolor (TV) were enrolled and were assigned into 2 groups. Group A (n=18) received fluconazole 400 mg single dose orally and Group B (n=12) received placebo. At the end of 2 weeks, 8 out of 18 (44.4\%) of Group A patients and 1 out of 12 (8.3\%) of Group B showed mycological cure (P=0.08). Ten patients of Group A who had KOH positivity after 2 weeks were given 2nd dose of 400 mg fluconazole 2 weeks after the 1st dose. Nine of these (90\%) showed mycological cure at the end of subsequent 2 weeks. The difference between the efficacy of single dose fluconazole after 2 weeks and 2 doses of fluconazole after 4 weeks was statistically significant (P<0.01). None of the patients had any significant side effects. Therefore single dose therapy of fluconazole 400 mg is not satisfactory in TV. Instead, 2 doses of flluconazole (400 mg) given at 2 weeks intervals is safe and very effective.
This article was published in Indian J Dermatol Venereol Leprol and referenced in Journal of Microbial & Biochemical Technology

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