alexa Comparative haemodynamic and respiratory effects of midazolam and flunitrazepam as induction agents in cardiac surgery.
Microbiology

Microbiology

Journal of Microbial & Biochemical Technology

Author(s): Morel D, Forster A, Gardaz JP, Suter PM, Gemperle M

Abstract Share this page

Abstract 30 cardiac surgical patients were investigated for comparing the respiratory and haemodynamic repercussions of induction of anaesthesia with either flunitrazepam or 8-chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a] [1,4]benzodiazepine (midazolam, Ro 21-3981, Dormicum). The patients were premedicated with morphine, 0.15 mg/kg i.m., and divided into two groups: one group receiving flunitrazepam 0.03 mg/kg, the other midazolam 0.15 mg/kg injected i.v. over a 15-s period. The induction time and the respiratory depression were similar in both groups. A similar decrease in systolic, diastolic and mean arterial pressures was noted, with maximum decrease of mean arterial pressure of 21\% 5 min after injection of flunitrazepam, and of 19\% after injection of midazolam. Midazolam produced a significant but transient pulse acceleration of 4\% 1 min after the injection, while flunitrazepam produced a moderate decrease of the heart rate. These results indicate that in cardiac surgical patients midazolam produces a moderate respiratory and cardiovascular depression similar to flunitrazepam.
This article was published in Arzneimittelforschung and referenced in Journal of Microbial & Biochemical Technology

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords