Author(s): Kruszyski Z, JaworskaGrajek M, Wiewirowski K, Warzybok K
A group of 40 women having undergone abdominal gynecological operations were studied for the comparative evaluation of nalbuphine and morphine. The analgetics were used to relieve postoperative pain in the technique of double blind trial. 20 women were administered 20 mg of nalbuphine and 20 women were administered 10 mg of morphine. Within 6 hours following the administered of each of the drugs, the authors evaluated the analgetic effectiveness, haemodynamic, ventilatory and gasometric parameters. Most of the women showed satisfactory and comparable analgetic effectiveness of the two drugs for six hours. No influence was found of any of the analgetics on the physiological parameters examined. The frequency and intensification of side-effects were the same both after administering nalbuphine and morphine. In the authors' opinion, in a proper dose, nalbuphine is an analgetic equal to morphine with respect to analgetic effectiveness and time of pharmacological action.