alexa Comparison of carotid plaque ulcer detection using contrast-enhanced and time-of-flight MRA techniques.


Journal of Vascular Medicine & Surgery

Author(s): Etesami M, Hoi Y, Steinman DA, Gujar SK, Nidecker AE,

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Abstract BACKGROUND AND PURPOSE: Ulceration in carotid plaque is a risk indicator for ischemic stroke. Our aim was to compare plaque ulcer detection by standard TOF and CE-MRA techniques and to identify factors that influence its detection. MATERIALS AND METHODS: Carotid MR imaging scans were acquired on 2066 participants in the ARIC study. We studied the 600 thickest plaques. TOF-MRA, CE-MRA, and black-blood MR images were analyzed together to define ulcer presence (plaque surface niche ≥2 mm in depth). Sixty ulcerated arteries were detected. These arteries were randomly assigned, along with 40 nonulcerated plaques from the remaining 540, for evaluation of ulcer presence by 2 neuroradiologists. Associations between ulcer detection and ulcer characteristics, including orientation, location, and size, were determined and explored by CFD modeling. RESULTS: One CE-MRA and 3 TOF-MRAs were noninterpretable and excluded. Of 71 ulcers in 56 arteries, readers detected an average of 39 (55\%) on both TOF-MRA and CE-MRA, 26.5 (37.5\%) only on CE-MRA, and 1 (1.5\%) only on TOF-MRA, missing 4.5 (6\%) ulcers by both methods. Ulcer detection by TOF-MRA was associated with its orientation (distally pointing versus perpendicular: OR = 5.57 [95\% CI, 1.08-28.65]; proximally pointing versus perpendicular: OR = 0.21 [95\% CI, 0.14-0.29]); location relative to point of maximum stenosis (distal versus isolevel: OR = 5.17 [95\% CI, 2.10-12.70]); and neck-to-depth ratio (OR = 1.96 [95\% CI, 1.11-3.45]) after controlling for stenosis and ulcer volume. CONCLUSIONS: CE-MRA detects more ulcers than TOF-MRA in carotid plaques. Missed ulcers on TOF-MRA are influenced by ulcer orientation, location relative to point of maximum stenosis, and neck-to-depth ratio. This article was published in AJNR Am J Neuroradiol and referenced in Journal of Vascular Medicine & Surgery

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