Author(s): Stiborov M, Frei E, Schmeiser HH, Stiborov M, Frei E, Schmeiser HH
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Abstract Carcinogenic azo dyes (dimethylaminoazobenzene, Sudan I) and N-nitrosamines (N-nitrosomethylaniline, N-nitrosomethylbenzylamine) are oxidized by cytochrome P-450 isoenzymes and peroxidase yielding metabolites which in vitro bind to DNA and transfer RNA (tRNA). The parallelism and differences in oxidative reactions are described. Peroxidase is more effective than P-450 in activating reactions of some carcinogens studied. The presence of either of these enzymes is supposed to be responsible for the organ and/or cell type specific effects of the carcinogens studied.
This article was published in Gen Physiol Biophys
and referenced in Journal of Developing Drugs