alexa Comparison of ER, PR and HER-2 neu (C-erb B 2) reactivity pattern with histologic grade, tumor size and lymph node status in breast cancer.
Oncology

Oncology

Journal of Carcinogenesis & Mutagenesis

Author(s): AzizunNisa, Bhurgri Y, Raza F, Kayani N

Abstract Share this page

Abstract INTRODUCTION: Carcinoma of the breast is the most common malignancy of women in Karachi. The current study was conducted with the objective of assessing estrogen receptor (ER), progesterone receptor (PR) and HER-2/neu reactivity patterns of mammary cancers for correlation with histologic grade, tumor size and lymph node metastasis. MATERIALS AND METHODS: One hundred and fifty modified mastectomy specimens received at the section of histopathology, Aga Khan University Hospital, were selected using a non-probability sampling method. RESULTS: Mean age of the patients was 48.3 years (95\%CI 46.5, 50.2). The left breast was more commonly involved (57\%). Tumor size ranged from 0.3 to 15.0 cm; 12\% were >2.0 and 35.3\% were >5.0 cm in diameter. The predominant morphology was infiltrating ductal carcinoma (85.3\%). The majority of the cases presented as grade II (55.3\%) lesions with tumor necrosis (70\%) and lymph node involvement (71.3\%). ER and PR were positive in 32.7\% and 25.3\% cases respectively. HER-2/neu was positive (3+) in 24.7\%. ER positivity increased and HER-2/neu positivity decreased with rising age. ER and PR expression was significantly lower in HER-2/neu positive as compared with HER-2/neu negative tumors (ER 83.8\% vs 69.8\%; PR 91.9\% vs 77.8\%). In the HER-2/neu positive tumors, ER and PR expression in high grade tumors was significantly decreased compared with intermediate grade tumors (ER 5.6\% vs 10.5; PR 0\% vs 5.3\%). ER expression in the HER-2/neu positive, large sized tumors was also significantly decreased compared with smaller tumors (ER 6.3\% vs 11.8). CONCLUSIONS: ER and PR expression in breast cancers in the current study was found to be comparable to published international data, but the frequency of HER-2/neu expression was higher, possibly reflecting a young age at diagnosis. Assessment of prognostic markers for the clinical management of breast cancer patients is strongly advocated to provide best therapeutic options.
This article was published in Asian Pac J Cancer Prev and referenced in Journal of Carcinogenesis & Mutagenesis

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords