alexa Comparison of physician- and self-collected genital specimens for detection of human papillomavirus in men.
Infectious Diseases

Infectious Diseases

Journal of AIDS & Clinical Research

Author(s): Hernandez BY, McDuffie K, Goodman MT, Wilkens LR, Thompson P, , Hernandez BY, McDuffie K, Goodman MT, Wilkens LR, Thompson P,

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Abstract There is currently no consensus regarding the most appropriate methods of sampling for the detection of genital human papillomavirus (HPV) in men. We employed a recently developed collection method involving abrasion and moistened swabbing of the genital skin surface for the detection of HPV in a cohort of 136 university-affiliated males in Hawaii. Genital specimens collected by physicians using this method were compared with self-collected specimens from the same individuals obtained 24 h later. Self-collected specimens yielded a greater proportion of sufficient specimens than physician-collected specimens. HPV detection was comparable in physician- and self-collected specimens; detection was highest in the penile shaft (51.2\% and 51.5\%, respectively, P = 0.96), followed by the scrotum (41.2\% and 46.2\%, P = 0.43), the glans/coronal sulcus (31.9\% and 33.1\%, P = 0.84), and the foreskin (33.3\% and 28.6\%, P = 0.74). Site-specific agreement in HPV detection between paired physician- and self-collected samples ranged from 67.2\% (kappa = 0.34) for the penile shaft to 95.0\% (kappa = 0.89) for the foreskin. There was a high degree of concordance in HPV genotypes in HPV-positive pairs. The most common type was HPV type 84, which comprised approximately 15\% of the specimens. The emery paper-swab method offers an efficient sampling method for genital HPV DNA detection in men that could be used both within and outside of the clinical setting.
This article was published in J Clin Microbiol and referenced in Journal of AIDS & Clinical Research

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