Author(s): MolinaGarrido MJ, GuillenPonce C
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Abstract INTRODUCTION AND OBJECTIVES: We have tested two frailty screening tools (the Barber Questionnaire [BQ] and the Vulnerable Elderly Survey [VES-13]) to select patients who may benefit from Comprehensive Geriatric Assessment (CGA). MATERIALS AND METHODS: We included women ≥ 65 years old, diagnosed with early breast cancer at the University General Hospital in Elche. We compared impairment in the BQ score (score <0 vs. > 0) and impairment in the VES-13 score (<3 vs. ≥ 3), with impaired CGA results (< 2 scales with deficits vs. ≥2). We evaluated the diagnostic performance of both questionnaires by Area Under Curve [AUC] and analyzed their concordance with CGA scales (intraclass correlation coefficient [ICC]). RESULTS: Forty-one women were included. The risk of frailty was 41.76\%, 29.3\%, and 55.7\% when evaluated with BQ, VES-13 and CGA, respectively. The correlation between BQ and CGA was fair (ICC=0.672), but between VES-13 and CGA was very good (ICC=0.814). The predictive capacity of the BQ and the VES-13 for detecting frailty risk was intermediate (AUC=0.719) and high (AUC=0.876), respectively. CONCLUSIONS: We propose the use of the VES-13 in older women with early breast cancer and the implementation of CGA when VES-13<3. Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.
This article was published in Crit Rev Oncol Hematol
and referenced in Journal of Cancer Science & Therapy