alexa Complex karyotype predicts for inferior outcomes following reduced-intensity conditioning allogeneic transplant for chronic lymphocytic leukaemia.
Microbiology

Microbiology

Journal of Antivirals & Antiretrovirals

Author(s): Jaglowski SM, Ruppert AS, Heerema NA, Bingman A, Flynn JM,

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Abstract Complex karyotype (CK) on metaphase cytogenetics discriminates poor outcome in chronic lymphocytic leukaemia (CLL) patients undergoing salvage treatment; we hypothesized that it might provide prognostic information for patients undergoing allogeneic stem cell transplant. Fifty-one CLL patients were analysed following transplant; 18-month overall survival (OS), event-free survival (EFS) and cumulative incidence of progression estimates were 35\%, 14\% and 63\%, respectively, in patients with CK (n = 19) versus 83\%, 68\% and 29\% in patients without (n = 32) (P ≤ 0·0001, P ≤ 0·0001, and P = 0·02). In patients with high-risk interphase cytogenetics, CK remained predictive of worse OS (P = 0·02) and EFS (P = 0·009). These findings support further evaluation of metaphase karyotype in transplant risk assessment. © 2012 Blackwell Publishing Ltd.
This article was published in Br J Haematol and referenced in Journal of Antivirals & Antiretrovirals

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