alexa Complex networks orchestrate epithelial-mesenchymal transitions.
Oncology

Oncology

Journal of Integrative Oncology

Author(s): Thiery JP

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Epithelial-mesenchymal transition is an indispensable mechanism during morphogenesis, as without mesenchymal cells, tissues and organs will never be formed. However, epithelial-cell plasticity, coupled to the transient or permanent formation of mesenchyme, goes far beyond the problem of cell-lineage segregation. Understanding how mesenchymal cells arise from an epithelial default status will also have a strong impact in unravelling the mechanisms that control fibrosis and cancer progression.

This article was published in Nat Rev Mol Cell Biol and referenced in Journal of Integrative Oncology

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