Author(s): Cramer JA, Scheyer RD, Mattson RH
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Abstract Adherence to prescribed drug dosing regimens declined substantially during the interval between clinic visits and drug level tests. Using microelectronic monitors to observe pill-taking habits, 20 patients averaged 88\% compliance before and 86\% compliance after the visit, but this dropped to 67\% compliance a month later. These data indicate that spot drug levels do not represent long-term "steady-state" drug serum concentrations.
This article was published in Arch Intern Med
and referenced in Pharmaceutica Analytica Acta