alexa Composition and antimicrobial activity of Achillea clavennae L. essential oil.


Medicinal Chemistry

Author(s): Bezi N, Skocibusi M, Dunki V, Radoni A

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Abstract The volatile constituents of Achillea clavennae L. (Asteraceae), rare plant of Europe, have been analysed using GC/MS. Twenty- five components making up 81.6\% of the oil were characterized with camphor (29.5\%), myrcene (5.5\%), 1,8-cineole (5.3\%), beta-caryophyllene (5.1\%) and linalool (4.9\%) being the major constituents. The essential oil was evaluated for antibacterial and antifungal activities. The screening of the antimicrobial activity of essential oil was conducted by a disc diffusion test against Gram-positive (Bacillus subtilis, Bacillus cereus, Staphylococcus aureus, Streptococcus faecalis), Gram-negative (Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Proteus mirabilis) and fungal organisms (Aspergillus niger, Aspergillus fumigatus, Candida albicans). The activity was more pronounced against Gram-negative and fungal organisms than against Gram-positive bacteria. A. clavennae oil was found to possess antimicrobial activity against Klebsiella pneumoniae, Pseudomonas aeruginosa and all fungal organisms. Copyright 2003 John Wiley & Sons, Ltd. This article was published in Phytother Res and referenced in Medicinal Chemistry

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