alexa Concentrations of free carnosine (a putative membrane-protective antioxidant) in human muscle biopsies and rat muscles.


Journal of Clinical Toxicology

Author(s): Stuerenburg HJ, Kunze K

Abstract Share this page

Abstract Carnosine has possible functional effects on skeletal muscle contractility, along with membrane-protective, antioxidant effects. We determined tissue free carnosine concentrations in skeletal muscles from patients with neuromuscular diseases and in skeletal and heart muscles from rats of various ages. The effects of age, gender and diagnostic category on free carnosine levels in patients with neuromuscular diseases were analyzed by a stepwise multiple linear regression model. The age of the patients emerged as a significant negative predictor of carnosine concentrations (R=-0.40, P<0.05). Free carnosine concentrations in rat skeletal muscles also showed a significant negative correlation with the ages of the rats (male rats: R=-0.49, P<0.05; female rats: R=-0.56, P<0.05). Only the diagnostic category amyotrophic lateral sclerosis (ALS) emerged as a significant negative predictor compared to the control group in the stepwise regression model, this was confirmed by Wilcoxon Signed Rank Test (P<0.05). We conclude that the age-related decline in muscle mass, strength and function is associated with decreased tissue concentrations of the putative membrane-protective antioxidant carnosine. In addition we found decreased carnosine tissue concentrations in ALS. The reduction in carnosine content might be caused by progressive denervation processes.
This article was published in Arch Gerontol Geriatr and referenced in Journal of Clinical Toxicology

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Relevant Topics

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version