alexa Conformational variability in the refined structure of the chaperonin GroEL at 2.8 A resolution.
Chemistry

Chemistry

Journal of Physical Chemistry & Biophysics

Author(s): Braig K, Adams PD, Brnger AT

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Abstract Improved refinement of the crystal structure of GroEL from Escherichia coli has resulted in a complete atomic model for the first 524 residues. A new torsion-angle dynamics method and non-crystallographic symmetry restraints were used in the refinement. The model indicates that conformational variability exists due to rigid-body movements between the apical and intermediate domains of GroEL, resulting in deviations from strict seven-fold symmetry. The regions of the protein involved in polypeptide and GroES binding show unusually high B factors; these values may indicate mobility or discrete disorder. The variability of these regions may play a role in the ability of GroEL to bind a wide variety of substrates.
This article was published in Nat Struct Biol and referenced in Journal of Physical Chemistry & Biophysics

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