alexa Conquering absolute contraindications to transplantation: positive-crossmatch and ABO-incompatible kidney transplantation
Nephrology

Nephrology

Journal of Kidney

Author(s): Dean PG, Gloor JM, Stegall MD

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A POSITIVE CROSSMATCH AND ABO BLOOD GROUP incompatibility have long been considered absolute contraindications to kidney transplantation. Early experience showed that the presence of antibodies in the recipient’s serum against donor HLA or blood group antigens caused immediate or early loss of the renal allograft. However, over the past few years, novel protocols designed to reduce anti-donor antibody have allowed successful transplantation in both ABO-incompatible and positivecrossmatch donor/recipient combinations. In this review, we describe the current understanding of antibody barriers to renal transplantation, the clinical protocols used to overcome these barriers, and the future direction that this field of transplantation is likely to take.

This article was published in Surgery and referenced in Journal of Kidney

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