Author(s): Dandekar T, Snel B, Huynen M, Bork P
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Abstract A systematic comparison of nine bacterial and archaeal genomes reveals a low level of gene-order (and operon architecture) conservation. Nevertheless, a number of gene pairs are conserved. The proteins encoded by conserved gene pairs appear to interact physically. This observation can therefore be used to predict functions of, and interactions between, prokaryotic gene products.
This article was published in Trends Biochem Sci
and referenced in Journal of Proteomics & Bioinformatics