Author(s): Greil J, Wyss PA, Ludwig K, Bonakdar S, Scharf J, , Greil J, Wyss PA, Ludwig K, Bonakdar S, Scharf J,
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Abstract Acute renal failure is a rare but very severe side-effect of methotrexate (MTX) treatment requiring extracorporeal detoxification. A new detoxification regime, consisting of a haemodiafiltration (HDF) and continuous plasma resin perfusion (PRP) over anion exchange resin column with high affinity for MTX, was used for treatment of MTX-induced acute renal failure in a 2-year-old boy with medulloblastoma. More than 99\% of MTX was removed from plasma by perfusion over the resin column resulting in a marked decrease of MTX plasma half-life. No haematological complications occurred. CONCLUSION: The use of PRP alone or in combination with HDF is a new and effective treatment strategy for extracorporeal detoxification of MTX.
This article was published in Eur J Pediatr
and referenced in Journal of Drug Metabolism & Toxicology