Author(s): Febbraio MA, Pedersen BK
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Abstract The concentration of plasma interleukin-6 (IL-6) increases during physical exercise, but until recently the cellular origin of this increase has been unknown. Recent work has identified that skeletal muscle is a major source of this increase and the release of IL-6 from muscle can mediate metabolic processes. IL-6 is, therefore, the first identified "myokine" released from muscle that can now be termed an endocrine organ.
This article was published in Exerc Sport Sci Rev
and referenced in Journal of Genetic Syndromes & Gene Therapy